The fiscal year of 2007 is the year of more than 2,000 citation hits of the first GPCR structure paper, “Crystal structure of Bovine Rhodopsin” was reported using SPring-8 in 2,000 as well as the 10th anniversary of SPring-8. The 2007 is the jumping year of the structure determination on human integral membrane proteins as the major drug targets; human b2-adrenergic receptor, leukotriene C4 synthase and five-lipoxygenase activating protein. We organize the symposium the integral membrane protein structure determination from the view of their application in the next decade. (Presentation language: English)