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RIKEN symposium Structural Biology (VIII)(2003.1.23〜1.24)

"Structural biology of protein complexes : from structure to mechanisms"

23rd - 24 th , January, 2003 JASRI Hukyuto at SPring-8, Japan

01
Due to the recent progresses in structural biology,many structures of protein complexes that play important cellular roles have been solved. However, it is not yet obvious how, from the obtained static structures, we can successfully understand the mechanisms. In this RIKEN symposium, the oral presentations by oversea and domestic inivited speakers will be focused on this problem. In the poster session, recent works undertaken in the RIKEN Harima Institure and SPring-8 will be presented and discussed.

23th Jannuary (Thu)
10:30-12:30 Poster (1)
13:30-13:40 Beginning Structure and function of membrane protein(1)
Y.Maeda (Structural Bilchemistry, RIKEN Harima)
Session 1 Structure and function of membrane protein(1)
13:40-14:10 S.Murakami(Institute of Scientific and Industrial Research, Osaka Univ.& PRESTO) Crystal structure of bacterial multidrug efflux transporter AcrB.
14:10-14:40 J. Takagi(Center for Blood Research, Harvard medeical school, Boston) Conformational modulation of the ligand binding function of integrins.
14:40-15:00 Coffee Break
Session 2 Various approaches to understand the protein functions
15:00-15:30 A. Kitao(Center for promotion of computational science and engineering, JAERI) Jumping-among -minima model for protein dynamics in the native state.
16:00-16:30 M. Nakasako(Science and Techonology, Keio Univ.) Influence of water on structure and dynamics of proteins.
16:30-17:30 Poster(2)&Coffee
17:30-19:30 Reception @SP-ring8dinning room
The poster session room will be open by 22:00
24th Jannuary (Fri)
Session 3 Dynamics of filamentous structure
9:00-9:30 T. Oda(Structural Biochemistry, RIKEN Harima) Modeling of F-actin:mechanism of F-actin stabilization by natural drugs - phalloidin and dolastatin 11.
9:30-10:00 . Yamashita(Structural Biochemistry, RIKEN Harima) Crystal structure of CapZ : architecture of a heterodimer complex and mechanism for actin filament capping.
10:00-10:30 K. Yonekura(Frontier Biosciences, Osaka Univ.) Electron ryomicroscopy of flagellar structures.
10:30-10:45 Coffee Break
Session 4 Structure and function of membrane protein(2)
10:45-11:15 J.-R.Shen(Structural Biochemistry, RIKEN Harima) Mechanisms of light - induced electron transfer and water oxidation in photosystem II based on its three-dimensional structure.
11:15-11:45 S.Yokoyama(Cellular Signaling, RIKEN Harima) Crystal Structure of the complex of human epidermal growth factor and receptor extracellular domains.
11:45-12:15 K. Takeda(Theoretical Structural Biology, RIKEN Harima) Structures of LOl proteins involved in trafficking of outer-membrane lipoproteins in Gram-negative bacteria.
Session5 DNA / RNA binding machines
13:15-13:45 Dmitry G. Vassylyev (Cellular Signaling, RIKEN Harima) Structural studies of single- and multi-subunit RNA polymerases : High resolution structures of a bacterial RNA polymerase holoenzyme and T7 RNA polymerase elongation complex.
14:45-14:15 Tahir H. Tahirov(HTPF, RIKEN Harima) Mechanisms of pomoter DNA recognition by AML1/CBFbeta, Myb and C/EBPbeta.
14:30-14:40 Ending T. Iizuka(RIKEN Harima)

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