The final goal of this research project is the understanding of all fundamental biological phenomena in a cell based on three-dimensional structure and function of all molecules. As a model organism for the structural and functional studies, an extremely thermophilic bacterium, Thermus thermophilus HB8, is very promising, because of the small genome size (2 Mbp), the availability of genetic tools for functional analysis, and the thermostability of its proteins. Using the protein structural information, this research group aims to reveal the functional information on a genome-wide scale by analyzing mRNA expression (transcriptomics), protein expression (proteomics) and metabolite dynamics (metabolomics). This research aims to establish the next basis of the prediction of the biological responses.

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